Article

Distinct 3D contacts and phenotypic consequences of adjacent non-coding loci in the epigenetically quiescent regions

2023-09-13

Abstract excerpt

Non-coding regions of the human genome are important for functional regulations, but their mechanisms remain elusive. We used machine learning to guide a CRISPR screening on hubs (i.e. non-coding loci forming many 3D contacts) and significantly increased the discovery rate of hubs essential for cell growth. We found no clear genetic or epigenetic differences between essential and nonessential hubs, but we observed...

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Identifiers and source

Literature Corpus work: 44341172-fd42-53b9-8342-b590fe471271
DOI: 10.1101/2023.09.11.557110

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