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Targeted mutations on 3D hub loci alter spatial interaction environment

2015-11-09

Abstract excerpt

Many disease-related genotype variations (GVs) reside in non-gene coding regions and the mechanisms of their association with diseases are largely unknown. A possible impact of GVs on disease formation is to alter the spatial organization of chromosome. However, the relationship between GVs and 3D genome structure has not been studied at the chromosome scale. The kilobase resolution of chromosomal structures measu...

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Identifiers and source

Literature Corpus work
7199720f-af31-5ecb-8eaf-87b888b9bf35
DOI
10.1101/030999
Open publication

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Targeted mutations on 3D hub loci alter spatial interaction environmentDOI 10.1101/030999
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