Article
Large-scale functional organization of long-range chromatin interaction networks.
Cell reports - 29 Nov 2012
Sandhu Kuljeet Singh, Li Guoliang, Poh Huay Mei, Quek Yu Ling Kelly, Sia Yee Yen, Peh Su Qin, Mulawadi Fabianus Hendriyan, Lim Joanne, Sikic Mile, Menghi Francesca, Thalamuthu Anbupalam, Sung Wing Kin, Ruan Xiaoan, Fullwood Melissa Jane, Liu Edison, Csermely Peter, Ruan Yijun
Abstract excerpt
Chromatin interactions play important roles in transcription regulation. To better understand the underlying evolutionary and functional constraints of these interactions, we implemented a systems approach to examine RNA polymerase-II-associated chromatin interactions in human cells. We found that 40% of the total genomic elements involved in chromatin interactions converged to a giant, scale-free-like,...
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