Article

Proteomic discovery of chemical probes that perturb protein complexes in human cells

2022-12-13

Abstract excerpt

<h4>Summary</h4> Most human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such “binding-first” assays affect protein function, nonetheless, often remains unclear. Here, we describe a “function-first” proteomic strategy that uses size exclusion chromatography (SEC) to assess the global...

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Literature Corpus work: 43b2befd-14b3-5f8c-8557-39dd21cd3818
DOI: 10.1101/2022.12.12.520090

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