Article

Electrophile scanning by chemical proteomics reveals a potent pan-active DUB probe for investigation of deubiquitinase activity in live cells

2022-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Deubiquitinases (DUBs) are proteases that hydrolyze isopeptide bonds linking ubiquitin to protein substrates, which can lead to reduced substrate degradation through the ubiquitin proteasome system. Deregulation of DUB activity has been implicated in many disease states, including cancer, neurodegeneration and inflammation, making them potentially attractive targets for therapeutic intervention....

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Literature Corpus work: 6e84ee8f-3f63-5b31-b801-a7b5a2c6a008
DOI: 10.1101/2022.09.28.509970

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