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Expanding the ligandable proteome by paralog hopping with covalent probes

2024-01-20

Abstract excerpt

More than half of the ∼20,000 protein-encoding human genes have at least one paralog. Chemical proteomics has uncovered many electrophile-sensitive cysteines that are exclusive to a subset of paralogous proteins. Here, we explore whether such covalent compound-cysteine interactions can be used to discover ligandable pockets in paralogs that lack the cysteine. Leveraging the covalent ligandability of C109 in the cy...

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Literature Corpus work
b8883bc4-b8ff-5c0b-b569-c01b6e790a48
DOI
10.1101/2024.01.18.576274
Open publication

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Expanding the ligandable proteome by paralog hopping with covalent probesDOI 10.1101/2024.01.18.576274
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