Article

Assessment of native mass spectrometry as a screening method to identify and characterize RNA-targeting small molecules

2025-02-10

Abstract excerpt

<h4>ABSTRACT</h4> The intentional targeting of RNA with small molecules is recognized as a viable pathway to new therapeutics with potential to vastly expand the proportion of the human genome considered druggable. The practical considerations to deliberately target RNA are largely under development, including optimal screening methods to identify small molecules for binding to RNA. Native mass spectrometry (nMS)...

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Literature Corpus work: 343502fe-aaba-5ee9-a285-c5db938684e6
DOI: 10.1101/2025.02.09.637332

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