Article

Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors

2025-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Activity-based protein profiling (ABPP) of stereoisomerically defined sets of electrophilic compounds (‘stereoprobes’) offers a versatile way to discover covalent ligands for proteins in native biological systems. Here we report the synthesis and chemical proteomic characterization of stereoprobes bearing a P(V)-oxathiaphospholane (OTP) reactive group. ABPP experiments identified numerous protei...

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Literature Corpus work: 7616ddbe-4734-5637-81ef-38dedef326d2
DOI: 10.1101/2025.01.31.635883

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