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Article

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

2023-01-17

Abstract excerpt

<h4>SUMMARY</h4> Pharmacological activation of the activating transcription factor 6 (ATF6) arm of the Unfolded Protein Response (UPR) has proven useful for ameliorating proteostasis deficiencies in a variety of etiologically diverse diseases. Previous high-throughput screening efforts identified the small molecule AA147 as a potent and selective ATF6 activating compound that operates through a mechanism involvin...

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Literature Corpus work
d9af7584-52f8-5dc3-a744-6981bfe8b9f8
DOI
10.1101/2023.01.16.524237
Open publication

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