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Article

Enzyme inhibitor discovery by activity-based protein profiling.

Annual review of biochemistry - 1 Jan 2014

Niphakis Micah J, Cravatt Benjamin F

Abstract excerpt

Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes. Selective inhibitors offer powerful probes for assigning functions to enzymes in native biological systems. Here, we discuss how the chemical proteomic platform activity-based protein profiling (ABPP) can be implemented to discover selective and in vivo-active inhibitors for enzymes. We further describe how these inhibitors have...

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PMID: 24905785
DOI: 10.1146/annurev-biochem-060713-035708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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