Article

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing

2018-12-17

Abstract excerpt

<h4>ABSTRACT</h4> Cellular proteostasis is maintained by stress-responsive signaling pathways such as the heat shock response (HSR), the oxidative stress response (OSR), and the unfolded protein response (UPR). Activation of these pathways results in the transcriptional upregulation of select subsets of stress-responsive genes that restore proteostasis and adapt cellular physiology to promote recovery following v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 281eb1ba-d961-5ec3-bcfa-df659cc70bf5
DOI: 10.1101/499046

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencingDOI 10.1101/499046Read

Mapping Stress-Responsive Signaling Pathways Induced by Mitochondrial Proteostasis PerturbationsSemantic proximity Read

Transcriptomics Unveil Canonical and Non-Canonical Heat Shock-Induced Pathways in Human Cell LinesSemantic proximity Read

Genome-wide, time-sensitive interrogation of the heat shock response under diverse stressors via ReporterSeqSemantic proximity Read

Dynamic Lipidome Reorganization in Response to Heat Shock StressSemantic proximity Read

Cellular proteostasis decline in human senescenceSemantic proximity Read

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing ModulatorsSemantic proximity Read

Cellular proteostasis decline in human senescenceSemantic proximity Read

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis RegulatorsSemantic proximity Read

Real-time transcriptomic profiling in distinct experimental conditionsSemantic proximity Read

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasisSemantic proximity Read

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specificSemantic proximity Read

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway.Semantic proximity Read