Article

Expedited Mapping of the Ligandable Proteome Using Fully Functionalized Enantiomeric Probe Pairs

2019-02-27

Abstract excerpt

A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ligand discovery with chemical proteomics to furnish global portraits of reversible small molecule-protein interactions in human cells. Excavating clear structure-activity relationships from t...

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Literature Corpus work: 22fb6c8f-f091-56f4-8fac-e23e95570c4b
DOI: 10.26434/chemrxiv.7764638.v1

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