Article

Human Coronavirus Infection Reorganizes Spatial Genomic Architecture in Permissive Lung Cells.

2024-03-13

Abstract excerpt

<title>Abstract</title> <p>Chromatin conformation capture followed by next-generation sequencing in combination with large-scale polymer simulations (4DHiC) produces detailed information on genomic loci interactions, allowing for the interrogation of 3D spatial genomic structures. Here, Hi-C data was acquired from the infection of fetal lung fibroblast (MRC5) cells with α-coronavirus 229E (CoV229E). Experimental...

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Literature Corpus work: 405097b9-d61d-5c11-b782-5b59d7f4b5f9
DOI: 10.21203/rs.3.rs-3979539/v1

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