Article

<i>De Novo</i> Prediction of Human Chromosome Structures: Epigenetic Marking Patterns Encode Genome Architecture

2017-08-07

Abstract excerpt

Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell type. Here, we show that this chromatin architecture can be predicted de novo using epigenetic data derived from ChIP-Seq. We exploit the idea that chromosomes encode a one-dimensional sequence of chromatin structural types. Interactions between these chromatin types determine the three-dimensional (3D) structural ense...

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Identifiers and source

Literature Corpus work: ffd52c23-3709-54e5-86ca-0ad33769555a
DOI: 10.1101/173088

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