Article

Chromatin folding variability across single-cells results from state degeneracy in phase-separation

2020-05-16

Abstract excerpt

Chromosome spatial organization controls functional interactions between genes and regulators, yet the molecular and physical mechanisms underlying folding at the single DNA molecule level remain to be understood. Here we employ models of polymer physics to investigate the conformations of two 2Mb-wide DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on the 3D structure of...

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Literature Corpus work: e2029325-c6ef-5634-a090-21f9107cdcc9
DOI: 10.1101/2020.05.16.099275

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