Article

The evolution of the human DNA replication timing program

2022-08-10

Abstract excerpt

DNA is replicated according to a defined spatiotemporal program that is linked to both gene regulation and genome stability. The evolutionary forces that have shaped replication timing programs in eukaryotic species are largely unknown. Here, we studied the molecular causes and consequences of replication timing evolution across 94 humans, 95 chimpanzees, and 23 rhesus macaques. Replication timing differences reca...

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Literature Corpus work: 3fd91195-cc39-5b0f-803b-b7ce16d3ceed
DOI: 10.1101/2022.08.09.503365

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