Article

Replication origins drive genetic and phenotypic variation in humans

2021-12-17

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication starts with the activation of the replicative helicases, polymerases and associated factors at thousands of origins per S-phase 1 . Due to local torsional constraints generated during licensing 2 and the switch between polymerases of distinct fidelity and proofreading ability following firing 3,4 , origin activation has the potential to induce DNA damage and mutagenesis. Howev...

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Literature Corpus work: a5333505-a9bf-5cad-a26d-cd9d523d8256
DOI: 10.1101/2021.12.16.472898

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