Replication Stress, Genomic Instability, and Replication Timing: A Complex Relationship.

Abstract excerpt

The replication-timing program constitutes a key element of the organization and coordination of numerous nuclear processes in eukaryotes. This program is established at a crucial moment in the cell cycle and occurs simultaneously with the organization of the genome, thus indicating the vital significance of this process. With recent technological achievements of high-throughput approaches, a very strong link has...

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• Cell Cycle
• DNA Replication
• Epigenesis, Genetic
• Genomic Instability
• Mutation