Article

The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem Cells

2020-05-10

Abstract excerpt

DNA replication follows a strict spatiotemporal program that intersects with chromatin structure and gene regulation. However, the genetic basis of the mammalian DNA replication timing program is poorly understood 1–3 . To systematically identify genetic regulators of DNA replication timing, we exploited inter-individual variation in 457 human pluripotent stem cell lines from 349 individuals. We show that the hum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa5e28b4-9a89-594b-8e23-f58596837005
DOI: 10.1101/2020.05.08.085324

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem CellsDOI 10.1101/2020.05.08.085324Read

RT States: systematic annotation of the human genome using cell type-specific replication timing programsSemantic proximity Read

Replication Timing Networks: a novel class of gene regulatory networksSemantic proximity Read

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read

MLL3/MLL4 enzymatic activity shapes DNA replication timingSemantic proximity Read

Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem CellsSemantic proximity Read

Telomere-to-telomere human DNA replication timing profilesSemantic proximity Read

Sequencing newly replicated DNA reveals widespread plasticity in human replication timingSemantic proximity Read

The evolution of the human DNA replication timing programSemantic proximity Read

High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read

High-throughput analysis of single human cells reveals the complex nature of DNA replication timing controlSemantic proximity Read

Repli-seq: genome-wide analysis of replication timing by next-generation sequencingSemantic proximity Read

Most human DNA replication initiation is dispersed throughout the genome with only a minority within previously identified initiation zonesSemantic proximity Read