Article

Polymerase ζ activity is linked to replication timing in humans: evidence from mutational signatures

2014-11-17

Abstract excerpt

Replication timing is an important determinant of germline mutation patterns, with a higher rate of point mutations in late replicating regions. Mechanisms underlying this association remain elusive. One of the suggested explanations is the activity of error-prone DNA polymerases in late-replicating regions. Polymerase ζ (pol ζ), an essential error-prone polymerase biased towards transversions, also has a tendency...

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Literature Corpus work: 93dd6b31-cca8-5a7a-b8d9-4053c38b8a94
DOI: 10.1101/011494

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