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Article

Human mutation rate associated with DNA replication timing.

Nature genetics - 1 Apr 2009

Stamatoyannopoulos John A, Adzhubei Ivan, Thurman Robert E, Kryukov Gregory V, Mirkin Sergei M, Sunyaev Shamil R

Abstract excerpt

Eukaryotic DNA replication is highly stratified, with different genomic regions shown to replicate at characteristic times during S phase. Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human genome. All classes of substitutions are affected, suggesting a generalized mechanism involving...

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Source

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Identifiers

PMID: 19287383
DOI: 10.1038/ng.363
PMCID: PMC2914101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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