Article

Uncovering topologically associating domains from three-dimensional genome maps with TADGATE

2024-06-14

Abstract excerpt

Topologically associating domains (TADs) emerge as indispensable units in three-dimensional (3D) genome organization, playing a critical role in gene regulation. However, accurately identifying TADs from sparse chromatin contact maps and exploring the structural and functional elements within TADs remain challenging. To this end, we develop a graph attention auto-encoder, TADGATE, to accurately identify TADs even...

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Literature Corpus work: 3fabb3e7-169b-5e53-84a4-eca58c01afe5
DOI: 10.1101/2024.06.12.598668

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