Article

DeDoc2 identifies and characterizes the hierarchy and dynamics of chromatin TAD-like domains in the single cells

2022-08-25

Abstract excerpt

Topologically associating domains (TAD) are functional chromatin units with hierarchical structure. However, the existence, prevalence and dynamics of such hierarchy in single cells remain unexplored. Here, we report a new generation TAD-like domain (TLD) detection algorithm, named deDoc2, to decode the hierarchy of TLDs in single cells. With dynamic programming, deDoc2 seeks genome partitions with global minimal...

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Literature Corpus work: 9f98e531-c8e7-56c4-b715-37c1b4ddcb3f
DOI: 10.1101/2022.08.23.505046

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