Article

DeDoc2 identifies and characterizes the hierarchy and dynamics of chromatin TAD-like domains in the single cells

2022-09-19

Abstract excerpt

Topologically associating domains (TAD) are functional chromatin units with hierarchical structure. However, the existence, prevalence and dynamics of such hierarchy in single cells remain unexplored. Here, we report a new generation TAD-like domain (TLD) detection algorithm, named deDoc2, to decode the hierarchy of TLDs in single cells. With dynamic programming, deDoc2 seeks genome partitions with global minimal...

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Literature Corpus work: e2e616a1-7736-5fa1-a2fd-df527043e2fe
DOI: 10.21203/rs.3.rs-1863314/v1

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