Article

Deep learning framework ChIANet predicts protein-mediated chromatin architecture across functional contexts

2026-02-25

Abstract excerpt

<h4>ABSTRACT</h4> The spatial organization of the genome is dynamically shaped by chromatin-binding proteins, yet how protein-mediated three-dimensional (3D) architectures are specified across functional contexts remains incompletely understood. Here we present ChIANet, a multimodal deep learning framework that enables de novo prediction of protein-mediated chromatin contact maps and loops from protein-binding p...

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Literature Corpus work: 5c45c31d-36b2-570a-9e9f-6a277797ac3c
DOI: 10.64898/2026.02.24.707640

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