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Article

A subset of topologically associating domains fold into mesoscale core-periphery networks.

Scientific reports - 2 Jul 2019

Huang Harvey, Chen Sunnia T, Titus Katelyn R, Emerson Daniel J, Bassett Danielle S, Phillips-Cremins Jennifer E

Abstract excerpt

Mammalian genomes are folded into a hierarchy of compartments, topologically associating domains (TADs), subTADs, and long-range looping interactions. The higher-order folding patterns of chromatin contacts within TADs and how they localize to disease-associated single nucleotide variants (daSNVs) remains an open area of investigation. Here, we analyze high-resolution Hi-C data with graph theory to understand...

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PMID: 31266973
DOI: 10.1038/s41598-019-45457-9
PMCID: PMC6606598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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