Article

Multiscale and integrative single-cell Hi-C analysis with Higashi

2020-12-15

Abstract excerpt

The advent of single-cell Hi-C (scHi-C) technologies offers an unprecedented opportunity to unveil cell-to-cell variability of 3D genome organization. However, the development of computational methods that can effectively enhance scHi-C data quality and extract 3D genome features in single cells remains a major challenge. Here, we report Higashi, a new algorithm that achieves state-of-the-art analysis of scHi-C da...

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Literature Corpus work: a2d9e568-5bfc-546a-9fbd-b8c7ec9ad9df
DOI: 10.1101/2020.12.13.422537

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