Article

Simultaneous smoothing and detection of topological units of genome organization from sparse chromatin contact count matrices with matrix factorization

2020-08-18

Abstract excerpt

The three-dimensional (3D) organization of the genome plays a critical role in gene regulation for diverse normal and disease processes. High-throughput chromosome conformation capture (3C) assays, such as Hi-C, SPRITE, GAM, and HiChIP, have revealed higher-order organizational units such as topologically associating domains (TADs), which can shape the regulatory landscape governing downstream phenotypes. Analysis...

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Literature Corpus work: 5fb1fd99-f147-557a-80d9-7986365ca630
DOI: 10.1101/2020.08.17.254615

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