Article

TRUHiC: A TRansformer-embedded U-2 Net to enhance Hi-C data for 3D chromatin structure characterization

2025-04-03

Abstract excerpt

High-throughput chromosome conformation capture sequencing (Hi-C) is a key technology for studying the three-dimensional (3D) structure of genomes and chromatin folding. Hi-C data reveals underlying patterns of genome organization, such as topologically associating domains (TADs) and chromatin loops, with critical roles in transcriptional regulation and disease etiology and progression. However, the sparsity of ex...

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Literature Corpus work: 2346620d-5bab-5ac0-8457-cc17b7f19b20
DOI: 10.1101/2025.03.29.646133

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