Article

DeTOKI identifies and characterizes the dynamics of chromatin topologically associating domains in a single cell

2021-02-24

Abstract excerpt

The human genome has a dynamic, well-organized hierarchical 3D architecture, including megabase-sized topologically associating domains (TAD). TADs are a key structure of the genome regulating nuclear processes, such as gene expression, DNA replication and damage repair. However, owing to a lack of proper computational tools, TADs have still not been systematically and reliably surveyed in single cells. In the pre...

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Literature Corpus work: b4c8611c-a0e7-5123-98ed-b67de0c6270e
DOI: 10.1101/2021.02.23.432401

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