Article

Single-nucleus multi-omics identifies shared and distinct pathways in Pick’s and Alzheimer’s disease

2024-09-08

Abstract excerpt

The study of transcriptomic and epigenomic variations in neurodegenerative diseases, particularly tauopathies like Pick’s disease (PiD) and Alzheimer’s disease (AD), offers insights into their underlying regulatory mechanisms. Here, we identified critical regulatory changes driving disease progression, revealing potential therapeutic targets. Our comparative analyses uncovered disease-enriched non-coding regions a...

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Literature Corpus work: 3f85d344-fafd-5daf-871e-2a305851b646
DOI: 10.1101/2024.09.06.611761

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