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Article

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states.

Nature communications - 14 May 2026

Han Xia, Rosenberg Gregory M, Kisling Vivianne M, Zhang Tao, Lee Chia-Yi, Ravi Ashvin, Melnik Mikhail, Bilousova Tina, Spina Salvatore, Nana Alissa L, Grinberg Lea T, Seeley William W, Gylys Karen H, Huckins Laura M, Raj Towfique, Brennand Kristen J, Rexach Jessica E

Abstract excerpt

The accumulation of abnormal tau protein selectively affects distinct brain regions and specific populations of neurons and glial cells in tau-related dementias, such as Alzheimer's disease, Pick's disease and progressive supranuclear palsy. Although the three disorders share the feature of tau protein pathology, the regulatory circuitry of non-coding genetic variants underlying risk-associated cell states...

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Identifiers

PMID: 42135303
DOI: 10.1038/s41467-026-73007-1
PMCID: PMC13376791

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