Article

Genome-scale transcriptional regulatory network models of psychiatric and neurodegenerative disorders

2017-09-19

Abstract excerpt

Genetic and genomic studies suggest an important role for transcriptional regulatory changes in brain diseases, but roles for specific transcription factors (TFs) remain poorly understood. We integrated human brain-specific DNase I footprinting and TF-gene co-expression to reconstruct a transcriptional regulatory network (TRN) model for the human brain, predicting the brain-specific binding sites and target genes...

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Literature Corpus work: 7779db8e-d36f-5dd2-ad5d-aeb7906d7cfb
DOI: 10.1101/190959

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