Article

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states

2025-06-04

Abstract excerpt

The accumulation of abnormal tau protein selectively affects distinct brain regions and specific populations of neurons and glial cells in tau-related dementias, such as Alzheimer’s disease (AD), Pick’s disease (PiD), and progressive supranuclear palsy (PSP). Although the three disorders share the feature of tau protein pathology, the regulatory circuitry of non-coding genetic variants underlying risk-associated c...

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Literature Corpus work: 237f5dfa-8495-575d-98c1-e85189fd9254
DOI: 10.1101/2025.06.02.657512

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