Article

Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist – Tsix locus

2025-01-05

Abstract excerpt

<h4>ABSTRACT</h4> Long noncoding RNAs (LncRNAs) are increasingly recognized as being involved in human physiology and diseases, but there is a lack of mechanistic understanding for the majority of lncRNAs. We comparatively tested proposed mechanisms of antisense lncRNA regulation at the X-chromosome Inactivation (XCI) locus. We find that due to stochasticity in transcription, different mechanisms based on the act...

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Literature Corpus work: 3efd4d8d-6fe1-5730-a7b9-72cb4f50e06a
DOI: 10.1101/2025.01.05.631290

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