Article
A long noncoding RNA influences the choice of the X chromosome to be inactivated.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2022
Hierholzer Andreas, Chureau Corinne, Liverziani Alessandra, Ruiz Nerea Blanes, Cattanach Bruce M, Young Alexander N, Kumar Manish, Cerase Andrea, Avner Phil
Abstract excerpt
X chromosome inactivation (XCI) is the process of silencing one of the X chromosomes in cells of the female mammal which ensures dosage compensation between the sexes. Although theoretically random in somatic tissues, the choice of which X chromosome is chosen to be inactivated can be biased in mice by genetic element(s) associated with the so-called X-controlling element (Xce). Although the Xce was first...
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