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Article

The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.

Nature structural & molecular biology - 1 Aug 2010

Royce-Tolland Morgan E, Andersen Angela A, Koyfman Hannah R, Talbot Dale J, Wutz Anton, Tonks Ian D, Kay Graham F, Panning Barbara

Abstract excerpt

One X chromosome, selected at random, is silenced in each female mammalian cell. Xist encodes a noncoding RNA that influences the probability that the cis-linked X chromosome will be silenced. We found that the A-repeat, a highly conserved element within Xist, is required for the accumulation of...

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Share to Chromosomes, Mammalian
Share to Protein Processing, Post-Translational
Share to Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Long Noncoding

Share to RNA Processing, Post-Transcriptional

Share to RNA, Untranslated

Share to Serine-Arginine Splicing Factors

Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 20657585
DOI: 10.1038/nsmb.1877
PMCID: PMC4336797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20657585-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.PMID 20657585Read ↗

Advances in understanding chromosome silencing by the long non-coding RNA Xist.Semantic proximity Read ↗

Chromosomal silencing and localization are mediated by different domains of Xist RNA.Semantic proximity Read ↗

Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expressionSemantic proximity Read ↗

Transcriptional stochasticity reveals multiple mechanisms of long non-coding RNA regulation at the Xist – Tsix locusSemantic proximity Read ↗

A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.Semantic proximity Read ↗

Integrated analysis of Xist upregulation and gene silencing at the onset of random X-chromosome inactivation at high temporal and allelic resolutionSemantic proximity Read ↗

Unleashing XIST from X-chromosome inactivationSemantic proximity Read ↗

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution.Semantic proximity Read ↗

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation.Semantic proximity Read ↗

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Role of the Xist gene in X chromosome choosing.Semantic proximity Read ↗

High-resolution RNA allelotyping along the inactive X chromosome: evidence of RNA polymerase III in regulating chromatin configuration.Semantic proximity Read ↗

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