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Article

Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.

Development (Cambridge, England) - 1 Jan 2008

Ohhata Tatsuya, Hoki Yuko, Sasaki Hiroyuki, Sado Takashi

Abstract excerpt

Expression of Xist, which triggers X inactivation, is negatively regulated in cis by an antisense gene, Tsix, transcribed along the entire Xist gene. We recently demonstrated that Tsix silences Xist through modification of the chromatin structure in the Xist promoter region. This finding prompted us to investigate the role of antisense transcription across the Xist promoter in Tsix-mediated silencing. Here, we...

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Share to Chromatin
Share to CpG Islands
Share to DNA, Antisense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Histones

Share to Polyadenylation

Share to RNA, Long Noncoding

Share to RNA, Untranslated

Source

Identifiers

PMID: 18057104
DOI: 10.1242/dev.008490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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