Article
The X as model for RNA's niche in epigenomic regulation.
Cold Spring Harbor perspectives in biology - 1 Sept 2010
Lee Jeannie T
Abstract excerpt
The X-linked region now known as the "X-inactivation center" (Xic) was once dominated by protein-coding genes but, with the rise of Eutherian mammals some 150-200 million years ago, became infiltrated by genes that produce long noncoding RNA (ncRNA). Some of the noncoding genes have been shown to play crucial roles during X-chromosome inactivation (XCI), including the targeting of chromatin modifiers to the X....
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