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Article

Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.

Molecular and cellular biology - 1 Nov 2016

Loos Friedemann, Maduro Cheryl, Loda Agnese, Lehmann Johannes, Kremers Gert-Jan, Ten Berge Derk, Grootegoed J Anton, Gribnau Joost

Abstract excerpt

In female mammals, X chromosome inactivation (XCI) is a key process in the control of gene dosage compensation between X-linked genes and autosomes. Xist and Tsix, two overlapping antisense-transcribed noncoding genes, are central elements of the X inactivation center (Xic) regulating XCI. Xist upregulation results in the coating of the entire X chromosome by Xist RNA in cis, whereas Tsix transcription acts as a...

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Share to Chromosomes, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27528619
DOI: 10.1128/MCB.00183-16
PMCID: PMC5064214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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