Article

Discovery of amyloid binders as chemical chaperone to block pathological α-synuclein aggregation in synucleinopathies

2026-03-31

Abstract excerpt

<title>Abstract</title> <p>The prion-like propagation and accumulation of pathogenic α-synuclein (α-syn) aggregates in the central nervous system are central drivers of Parkinson’s disease (PD) and related synucleinopathies, and remain an important therapeutic target. However, most reported anti-fibrillogenesis agents show limited efficacy in cells or in vivo, and their mechanisms are often poorly defined. Here,...

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Literature Corpus work: 3e51129a-d5a6-5036-9d88-bb0b65034fa8
DOI: 10.21203/rs.3.rs-6562222/v1

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