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Article

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein.

International journal of molecular sciences - 24 Jan 2018

Leitao Andre, Bhumkar Akshay, Hunter Dominic J B, Gambin Yann, Sierecki Emma

Abstract excerpt

α-Synuclein (αS) is an intrinsically disordered protein that is associated with Parkinson's disease (PD) through its ability to self-assemble into oligomers and fibrils. Inhibition of this oligomerization cascade is an interesting approach to developing therapeutical strategies and β-synuclein (βS) has been described as a natural negative regulator of this process. However, the biological background and molecular...

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Identifiers

PMID: 29364143
DOI: 10.3390/ijms19020334
PMCID: PMC5855556

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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