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Article

A <i>de novo</i> compound targeting α-synuclein improves deficits in models of Parkinson's disease

27 Sept 2016

Abstract excerpt

Abnormal accumulation and propagation of the neuronal protein α-synuclein has been hypothesized to underlie the pathogenesis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Here we report a de novo-developed compound (NPT100-18A) that reduces α-synuclein toxicity through a novel mechanism that involves displacing α-synuclein from the membrane. This compound interacts with a domain...

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PMID: 27679481
DOI: 10.1093/brain/aww238

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