Article

A targetable N-terminal motif orchestrates α-Synuclein oligomer to fibril conversion

2023-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Oligomeric species populated during α-synuclein aggregation are considered key drivers of neurodegeneration in Parkinson’s disease. However, the development of oligomer-targeting therapeutics is constrained by our limited knowledge of their structure and the molecular determinants driving their conversion to fibrils. PSMα3 is a nanomolar peptide binder of α-synuclein oligomers that inhibits aggr...

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Literature Corpus work: 9cd1b8c2-c9e3-57df-856c-29e3aee541a1
DOI: 10.1101/2023.02.10.527650

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