Article

Distinct neurotoxic TDP-43 fibril polymorphs can be generated by heterotypic interactions with α-synuclein

2022-06-16

Abstract excerpt

<h4>ABSTRACT</h4> Amyloid aggregates of specific proteins form important pathological hallmarks in many neurodegenerative diseases, defining neuronal degeneration and disease onset. Recently, increasing numbers of patients show co-morbidities and overlaps between multiple neurodegenerative diseases, presenting distinct phenotypes. Such overlaps are often accompanied by co-localizations of more than one amyloid pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68472a0c-6413-5ecb-ba90-8f5c537e3417
DOI: 10.1101/2022.06.14.496041

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct neurotoxic TDP-43 fibril polymorphs can be generated by heterotypic interactions with α-synucleinDOI 10.1101/2022.06.14.496041Read

Prion-like C-terminal domain of TDP-43 and α-Synuclein interact synergistically to generate neurotoxic hybrid fibrilsSemantic proximity Read

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in DiseaseSemantic proximity Read

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding AntibodiesSemantic proximity Read

Interaction between -Synuclein and Other Proteins in Neurodegenerative DisordersSemantic proximity Read

Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific PhenotypesSemantic proximity Read

Lipid-induced polymorphic amyloid fibrils formation by α-synucleinSemantic proximity Read

Secondary Protein Aggregates in Neurodegenerative Diseases: Almost the Rule Rather than the ExceptionSemantic proximity Read

Alpha-Synuclein in Neurodegeneration: From Shared Biology to Disease-Specific Phenotypes.Semantic proximity Read

Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of SynucleinopathySemantic proximity Read

Structural and Functional Insights into α-Synuclein Fibril PolymorphismSemantic proximity Read

Parkinson's disease-specific α-Synuclein variants potentially drive Lewy body formation by engaging in promiscuous and non-functional interactions.Semantic proximity Read

Initiation and progression of α-synuclein pathology in Parkinson’s diseaseSemantic proximity Read