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Article

Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.

Proceedings of the National Academy of Sciences of the United States of America - 27 Aug 2024

Liu Kaien, Tao Youqi, Zhao Qinyue, Xia Wencheng, Li Xiang, Zhang Shenqing, Yao Yuxuan, Xiang Huaijiang, Han Chao, Tan Li, Sun Bo, Li Dan, Li Ang, Liu Cong

Abstract excerpt

α-synuclein (α-syn) assembles into structurally distinct fibril polymorphs seen in different synucleinopathies, such as Parkinson's disease and multiple system atrophy. Targeting these unique fibril structures using chemical ligands holds diagnostic significance for different disease subtypes. However, the molecular mechanisms governing small molecules interacting with different fibril polymorphs remain unclear....

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Identifiers

PMID: 39172784
DOI: 10.1073/pnas.2321633121
PMCID: PMC11363296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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