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Article

Library-Derived Peptide Aggregation Modulators of Parkinson's Disease Early-Onset α-Synuclein Variants.

ACS chemical neuroscience - 15 Jun 2022

Watt Kathryn J C, Meade Richard M, Williams Robert J, Mason Jody M

Abstract excerpt

Parkinson's Disease (PD) is characterized by the accumulation of Lewy bodies in dopaminergic neurons. The main protein component of Lewy bodies, α-synuclein (αS), is also firmly linked to PD through the identification of a number of single point mutations that are autosomal dominant for early-onset disease. Consequently, the misfolding and subsequent aggregation of αS is thought to be a key stage in the...

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PMID: 35613323
DOI: 10.1021/acschemneuro.2c00190
PMCID: PMC9204772

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