Article

Structural polymorphism of α-synuclein fibrils alters pathway of Hsc70 mediated disaggregation

2024-12-04

Abstract excerpt

The pathological aggregation of α -synuclein into amyloid fibrils is a hallmark of synucleinopathies including Parkinson’s disease. Despite this commonality, synucleinopathies display divergent disease phenotypes that have been attributed to disease specific three-dimensional structures of α -synuclein fibrils, each with a unique toxic gain-of-function profile. The Hsc70 chaperone is remarkable in its ability to...

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Literature Corpus work: 33782839-ddaf-5bae-9eb8-6cf94fc13acd
DOI: 10.1101/2024.12.02.626355

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