Article

Targeting Hydrophobic Residues in the Alpha-Synuclein NAC Domain Disrupts Aggregation and Seed-Competent Fibril Formation

2024-10-03

Abstract excerpt

<title>Abstract</title> <p>Alpha-synuclein (αSyn) is a 14 kDa soluble and intrinsically disordered protein ubiquitously expressed in neurons. It plays a crucial role in synucleinopathies, where insoluble fibrils contribute to neurotoxicity and disease progression. The formation of these fibrils and their ability to seed further aggregation are central to αSyn pathology. Our study focused on the hydrophobic non-am...

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Literature Corpus work: 3e10bcda-3e03-5bfd-b125-6d9c0b73a7da
DOI: 10.21203/rs.3.rs-5191089/v1

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