Article

SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations

2024-01-03

Abstract excerpt

Cdt1 is a protein critical for DNA replication licensing and is well-established to be a binding partner of the minichromosome maintenance (MCM) complex. Cdt1 has also been demonstrated to have an emerging, “moonlighting” role at the kinetochore via direct binding to microtubules and to the Ndc80 complex. However, it is not known how the structure and conformations of Cdt1 could allow for these multiple, completel...

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Literature Corpus work: 3d4a8f1a-7222-5ec5-ba9b-11abdf8d512b
DOI: 10.1101/2024.01.03.573975

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